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Lan Yang, Haiyan Sun, Daozhen Chen, Mudan Lu, Junfeng Wang, Fei Xu, Lingqing Hu and Jianpin Xiao Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21 Prenatal Diagnosis 34

Version of Record online: 20 DEC 2013 | DOI: 10.1002/pd.4271

What's already known about this topic?

  • Noninvasive prenatal diagnosis of chromosome aneuploidies has been achieved by measuring the ratio of two alleles of a single-nucleotide polymorphism (SNP) in circulating placental messenger RNA in maternal plasma with digital PCR and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
  • The equipment and operating costs of those methods are high.

What does this study add?

  • In this study, we developed a molecular technology – Multiple SNaPshot assay – with rapidity, accuracy, and lower cost for noninvasive prenatal detection of trisomy 21.

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