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Eric Hildebrand, Bengt Källén, Ann Josefsson, Tomas Gottvall and Marie Blomberg Maternal obesity and risk of Down syndrome in the offspring Prenatal Diagnosis 34

Article first published online: 27 DEC 2013 | DOI: 10.1002/pd.4294

What's already known about this topic?

  • A combination of ultrasound and biochemistry is a well-studied method for risk assessment of fetal aneuploidy.

What does this study add?

  • Maternal obesity in very early pregnancy is associated with increased risk for Down syndrome in the newborn.
  • Combined first trimester screening for aneuploidies is equally effective for all body mass index categories.

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