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Leona C. Poon and Kypros H. Nicolaides First-trimester maternal factors and biomarker screening for preeclampsia Prenatal Diagnosis 34

Article first published online: 21 MAY 2014 | DOI: 10.1002/pd.4397

What's already known about this topic?

  • It is unclear whether early and late onset preeclampsia are one disease or two different diseases.
  • There are several maternal risk factors and first-trimester biomarkers that perform better for the prediction of early than late onset preeclampsia.
  • The independent predictive value of these markers has been poorly studied.

What does this study add?

  • Using multivariate analysis in a large study population, we have identified the independent predictive value of each obstetric, demographic and maternal serum markers.
  • Mathematical modelling suggests high predictive ability at a reasonable false positive rate; prospective studies are underway to confirm the predictive values.

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