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Hollian R. Phillipps, Sharon R. Ladyman and David R. Grattan Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat Physiological Reports 1

Version of Record online: 19 NOV 2013 | DOI: 10.1002/phy2.162

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Despite significantly elevated plasma leptin and insulin concentrations, and lower blood glucose levels, no significant changes in gene expression of pituitary adenylate cyclase–activated polypeptide (Pacap), brain-derived neurotrophic factor (Bdnf), or glucokinase in the ventromedial nucleus of the hypothalamus (VMN) were detected between nonpregnant and day 14 pregnant groups. These data suggest that loss of leptin and insulin sensitivity during pregnancy in the VMN might allow gene expression to be maintained at normal/control levels in this nucleus, despite marked changes in the levels of these important regulatory hormones. These data provide further evidence for development of leptin resistance in the VMN as an adaptive response during pregnancy.

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