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Jingtao Zhang, Nathaniel J. Fredin and David M. Lynn Erosion of multilayered films fabricated from degradable polyamines: Characterization and evidence in support of a mechanism that involves polymer hydrolysis Journal of Polymer Science Part A: Polymer Chemistry 44

Version of Record online: 28 JUL 2006 | DOI: 10.1002/pola.21613

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Multilayered polyelectrolyte assemblies fabricated with hydrolytically degradable poly(amino ester)s erode gradually in physiological media. Here we investigated the role of polymer hydrolysis in governing film erosion. Characterization using reflective infrared spectroscopy demonstrated changes consistent with polymer hydrolysis, and assemblies fabricated with a poly(amino amide) did not erode under similar conditions. Additional experiments using a deuterated buffer were consistent with a mechanism of erosion in which polymer hydrolysis plays a significant role. These results, when combined, provide support for the view that polymer hydrolysis plays an important role in the erosion of polyelec trolyte assemblies fabricated from degradable polyamines.

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