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Jean-François Lutz Polymerization of oligo(ethylene glycol) (meth)acrylates: Toward new generations of smart biocompatible materials Journal of Polymer Science Part A: Polymer Chemistry 46

Version of Record online: 24 APR 2008 | DOI: 10.1002/pola.22706

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Oligo(ethylene glycol)-based (macro)monomers allow the synthesis of novel biocompatible macromolecules with promising stimuli-responsive properties. For instance, well-defined random copolymers of 2-(2-methoxyethoxy)ethyl methacrylate (MEO2MA) and oligo(ethylene glycol) methacrylate (OEGMA) exhibit a lower critical solution temperature (LCST) in aqueous solution, which can be precisely adjusted by varying the comonomer composition. For example, cloud points of either 32 °C, 37 °C or 39 °C were observed in pure water for copolymers possessing in average respectively 5, 8 or 10% of OEGMA units per chain. Thus, these polymers can be used for building a wide variety of modern materials such as biosensors, artificial tissues, smart gels for chromatography and drug carriers. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

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