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Gorkem Yilmaz, Hojjat Toiserkani, Dilek Odaci Demirkol, Serhan Sakarya, Suna Timur, Yusuf Yagci and Lokman Torun Modification of polysulfones by click chemistry: Amphiphilic graft copolymers and their protein adsorption and cell adhesion properties Journal of Polymer Science Part A: Polymer Chemistry 49

Version of Record online: 18 NOV 2010 | DOI: 10.1002/pola.24424

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Well-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized by click chemistry and characterized. Protein adsorption characteristics of PSU-g-PAA were studied and found to be reduced when compared to the precursor PSU. This can be attributed to the pendant carboxylic acid functionalities, which readily ionized in neutral and basic media to produce negatively charged carboxylate ions. PSU-g-PAA membrane act as an electrostatic repulsion barrier against the negatively charged BSA, which (like other proteins in blood) carries negative charge in normal blood circumstances. Thus, adsorbed protein amount is found to be low at tested conditions similar with the physiological pH.

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