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Ze-Yong Li, Hui-Yuan Wang, Cao Li, Xiao-Lu Zhang, Xiao-Jun Wu, Si-Yong Qin, Xian-Zheng Zhang and Ren-Xi Zhuo Porphyrin-functionalized amphiphilic diblock copolypeptides for photodynamic therapy Journal of Polymer Science Part A: Polymer Chemistry 49

Version of Record online: 18 NOV 2010 | DOI: 10.1002/pola.24451

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A series of amphiphilic diblock copolypeptides (ADCs), 5-(4-aminophenyl)-10,15,20-triphenyl-porphyrin (APP) conjugated poly(l-leucine)-block-polylysine (APP-LnKm) with different molar ratios of L-leucine unit and lysine unit were designed and synthesized. It was found that the micellar structure was formed by the self-assembly of the ADCs. APP-L109K186 micelles exhibited no significant dark cytotoxicity and high photodynamic therapy efficacy against HepG2 and HeLa cells, which indicated APP-L109K186 micelles could be a novel carrier for cancer therapy.

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