Zhihua Wu, Xianghui Zeng, Yuning Zhang, Neus Feliu, Pontus Lundberg, Bengt Fadeel, Michael Malkoch and Andreas M. Nyström Linear-dendritic polymeric amphiphiles as carriers of doxorubicin—In vitro evaluation of biocompatibility and drug delivery Journal of Polymer Science Part A: Polymer Chemistry 50
This study focused on chemotherapeutic delivery vehicles constructed from four different amphiphilic linear-dendritic hybrid block copolymers, sequestering doxorubicin in their core. After drug loading, these constructs were found to deliver an efficient dose of drugs, resulting in significant killing of breast cancer cells in vitro. Kinetic studies indicated that the drug formulation in the polymer micelles slowed down the cell uptake compared with the nonformulated drug, but similar efficacy in viability reduction could be found. This suggests that these linear-dendritic hybrid materials have a beneficial effect on treatment efficacy and is an interesting architecture for drug delivery systems.
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