Xianghui Zeng, Yuning Zhang, Zhihua Wu, Pontus Lundberg, Michael Malkoch and Andreas M. Nyström Hyperbranched copolymer micelles as delivery vehicles of doxorubicin in breast cancer cells Journal of Polymer Science Part A: Polymer Chemistry 50
Four types of drug nanoparticles (NPs) based on amphiphilic hyperbranched block copolymers were developed for the delivery of the chemotherapeutic doxorubicin to breast cancer cells. These carriers have their hydrophobic interior layer composed of the hyperbranched aliphatic polyester, Boltorn® H30 or Boltorn® H40, while the outer hydrophilic shell was composed of about 5 poly(ethylene glycol) (PEG) segments. Flow cytometry and confocal scanning laser microscopy studies indicated that the cancer cells could internalize the DOX-loaded H30-PEG10k NPs, which contributed to the sustained drug release, and induced more apoptosis than free DOX did.
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