Bahar Yeniad, N. Oruç Köklükaya, Hemantkumar Naik, M. W. Martin Fijten, Cor E. Koning and Andreas Heise Synthesis of enantiopure homo and copolymers by raft polymerization and investigation of their enantioselective lipase-catalyzed esterification Journal of Polymer Science Part A: Polymer Chemistry 51
Enantiopure styrene derivatives with chiral secondary hydroxy groups were obtained by enantioselective reduction of the corresponding ketone using alcohol dehydrogenase. The homo and copolymerization of these monomers using reversible addition fragmentation chain transfer yielded enantiopure homo and copolymers. The polymer analogous esterification of the hydroxy groups with an enantioselective lipase was only possible on the (R)-enantiomers in agreement with the enantiomeric preference of the lipase. This selectivity was retained in mixtures of enantiopure polymers.
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