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Floraine Collette, Régis Delatouche, Christophe Blanquart, Fabien Gueugnon, Marc Grégoire, Philippe Bertrand and Valérie Héroguez Easy and effective method to produce functionalized particles for cellular uptake Journal of Polymer Science Part A: Polymer Chemistry 51

Article first published online: 21 SEP 2012 | DOI: 10.1002/pola.26357

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The synthesis of a biocompatible nanocarrier is described using two nonaggressive standardized procedures. In the first, an azido-terminated NB-PEO α-norbornenyl poly(ethylene oxide) macromonomer is functionalized by click chemistry and then polymerized by ROMP in dispersed media using Grubbs' Catalyst as initiator to form functionalized particles. In the second procedure, azide containing particles are synthesized and the functionalization occurs subsequently. This project presents an innovative approach where universal polymeric vectors can be functionalized using any alkyne-modified active molecule.

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