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Michael Danquah, Tomoko Fujiwara and Ram I. Mahato Lactic acid- and carbonate-based crosslinked polymeric micelles for drug delivery Journal of Polymer Science Part A: Polymer Chemistry 51

Version of Record online: 19 OCT 2012 | DOI: 10.1002/pola.26392

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mPEG-b-P(CB-co-LA-co-MAC) and mPEG-b-PMAC-b-P(CB-co-LA) were synthesized preparing micelles, which were stabilized by crosslinking via radical polymerization of double bonds in the core and interface. These crosslinked micelles demonstrated enhanced stability against extensive dilution with aqueous solvents and in the presence of serum. Bicalutamide-loaded crosslinked micelles were more potent compared to noncrosslinked micelles in inhibiting LNCaP cell proliferation. These results suggest crosslinked micelles to be promising drug delivery vehicles for chemotherapy.

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