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Yong Shen, Yinan Ma and Zhibo Li Facile synthesis of dendrimers combining aza-Michael addition with Thiol-yne click chemistry Journal of Polymer Science Part A: Polymer Chemistry 51

Article first published online: 15 NOV 2012 | DOI: 10.1002/pola.26429

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Dendrimers are a unique class of synthetic macromolecules with highly branched and globular architecture with promising biomedical applications. A highly efficient strategy was developed to make a fifth generation dendrimer within five steps using a combination of aza-Michael addition and Thiol-yne click reactions. All reactions are conducted under benign conditions in the absence of metal catalyst.

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