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Jae Min Bak and Hyung-il Lee Novel thermoresponsive fluorinated double-hydrophilic poly{[N-(2,2-difluoroethyl)acrylamide]-b-[N-(2-fluoroethyl)acrylamide]} block copolymers Journal of Polymer Science Part A: Polymer Chemistry 51

Version of Record online: 19 FEB 2013 | DOI: 10.1002/pola.26578

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Novel thermoresponsive double-hydrophilic fluorinated block copolymers, poly{[N-(2,2-difluoroethyl)acrylamide]-b-[N-(2-fluoroethyl)acrylamide]} (P2F-b-P1F), were successfully synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Mono-fluorine substituted poly[N-(2-fluoroethyl)acrylamide] (P1F) is water-soluble while di-fluorine substituted poly[N-(2,2-difluoroethyl)acrylamide] (P2F) exhibits an LCST in water around 26–28 °C. Temperature-induced formation and disruption of nanoaggregates were achieved by virtue of the thermoresponsive nature of the P2F block. Temperature-triggered release of a model hydrophobic drug, coumarin 102, was also demonstrated.

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