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Xueqi Qian, Zhengyang Jiang, Xianfu Lin and Qi Wu Tandem dynamic kinetic resolution and enzymatic polycondensation to synthesize mPEG-functionalized poly(amine-co-ester)-type chiral prodrugs Journal of Polymer Science Part A: Polymer Chemistry 51

Version of Record online: 14 FEB 2013 | DOI: 10.1002/pola.26594

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An efficient protocol to prepare amphiphilic poly(amine-co-ester) containing (R)-mexiletine with 99% ee by combining Candida antarctica lipase B/(Pd/C)-catalyzed dynamic kinetic resolution and subsequent polycondensation was developed. The copolymers can readily self-assemble into nanometer-scale-sized micelles with well-dispersed spheres, and their size distribution can be efficiently adjusted by changing the polymer concentration.

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