Ying Hao, Jinlin He, Mingzu Zhang, Yunfeng Tao, Jian Liu and Peihong Ni Synthesis and characterization of novel brush copolymers with biodegradable polyphosphoester side chains for gene delivery Journal of Polymer Science Part A: Polymer Chemistry 51
Novel PDMAEMA-based brush copolymers (PHEMA-g-PEEP)-b-PDMAEMA with biodegradable polyphosphoester side chains have been synthesized and characterized. At neutral pH condition, PDMAEMA segments would be partially protonated to produce some hydrophilic segments and possessed positive charges. Because of the chain entanglement and association of hydrophobic segments, the formed aggregates could condense DNA via electrostatic interaction and be served as a potential gene delivery vector.
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