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Mingying Yang, Wen He, Yajun Shuai, Sijia Min and Liangjun Zhu Nucleation of hydroxyapatite crystals by self-assembled Bombyx mori silk fibroin Journal of Polymer Science Part B: Polymer Physics 51

Article first published online: 29 JAN 2013 | DOI: 10.1002/polb.23249

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The mechanically robust properties of silk fibroin (SF) have prompted numerous investigations into its potential in biomaterials and scaffolds for tissue engineering. To prove that Bombyx mori SF mediates the nucleation of hydroxyapatite crystals (HAps) by its molecular self-assembly, atomic force microscopy observation of a co-solution of SF and simulated body fluid (SBF) indicated that SF incubated in SBF was self-assembled into a net, suggesting that nucleation of HAps of SF was controlled by its molecular self-assembly.

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