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Xi-Qiu Liu, Chun-Yang Sun, Xian-Zhu Yang and Jun Wang Polymeric-Micelle-Based Nanomedicine for siRNA Delivery Particle & Particle Systems Characterization 30

Article first published online: 22 FEB 2013 | DOI: 10.1002/ppsc.201200061

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Small interfering RNAs (siRNAs) are a rapidly emerging class of innovative medicines. However, siRNA delivery is the biggest challenge for their clinical application. The barriers impeding siRNA delivery, the different polymeric micelles of siRNA developed to date, their gene silencing or therapeutic activity, and advanced applications for the co-delivery of drugs and siRNA by these delivery systems are reviewed.

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