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Chor Yong Tay, Wanru Fang, Magdiel Inggrid Setyawati, Chee Peng Sum, Jianping Xie, Kee Woei Ng, Xiaodong Chen, Catherine Hsu Ling Hong and David Tai Leong Reciprocal Response of Human Oral Epithelial Cells to Internalized Silica Nanoparticles Particle & Particle Systems Characterization 30

Article first published online: 21 MAY 2013 | DOI: 10.1002/ppsc.201300111

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Nano-reciprocity of human oral bucal mucosa epithelial cells (TR146 cells) to silica nanoparticles (SiO2 NPs) is commonly found in consumer products. SiO2 NPs are able to associate, internalize, and translocate into the cell nucleus of TR146 cells, resulting in increased oxidative stress and mild inflammatory responses, but do not induce cell apoptosis or disrupt the cell cycle.

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