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Bong Jin Hong, Elden P. Swindell, Keith W. MacRenaris, Patrick L. Hankins, Anthony J. Chipre, Daniel J. Mastarone, Richard W. Ahn, Thomas J. Meade, Thomas V. O'Halloran and SonBinh T. Nguyen pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T1 MRI Contrast by Her2 Targeting Particle & Particle Systems Characterization 30

Article first published online: 10 JUL 2013 | DOI: 10.1002/ppsc.201300158

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A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and GdIII-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

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