Hong Yang, Yingzhe Zhou, Shan-Yu Fung, Licun Wu, Kevin Tsai, Rusung Tan, Stuart E. Turvey, Tiago Machuca, Marc de Perrot, Thomas K. Waddell and Mingyao Liu Amino Acid Structure Determines the Immune Responses Generated by Peptide–Gold Nanoparticle Hybrids Particle & Particle Systems Characterization 30
Version of Record online: 16 JUL 2013 | DOI: 10.1002/ppsc.201300213
By tuning the chemical modalities on gold nanoparticle surface using hexapeptide ligands the responses of immune cells (dendritic cells) to nanoparticles can be remarkably manipulated from minimum reaction (in the presence of negatively charged peptide ligands) to activation (in the presence of peptide ligands with aromatic rings containing amino acids).
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