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Yali Li, Zhida Zheng, Andrew Ramsey and Lingling Chen Analysis of peptides and proteins in their binding to GroEL Journal of Peptide Science 16

Article first published online: 1 SEP 2010 | DOI: 10.1002/psc.1288

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Small peptides are useful to reveal structural basis for GroEL-substrate protein interaction. This study compares various aspects of a peptide termed SBP with those of GroEL substrate proteins in their binding to GroEL. We found that peptides like SBP may represent many features of substrate proteins in their interaction with GroEL, but they can not mimic the binding cooperativity due to the lack of a contiguous linker that connects all the GroEL-bound peptides.

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