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Richard M. Epand and Raquel F. Epand Bacterial membrane lipids in the action of antimicrobial agents Journal of Peptide Science 17

Article first published online: 30 NOV 2010 | DOI: 10.1002/psc.1319

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A mechanism contributing to the antimicrobial action of certain agents is illustrated. The effect is a consequence of rearrangements of the bacterial membrane as a consequence of the interaction of a polycationic peptide (blue) selectively interacting with anionic lipid components (red) in the membrane and causing these lipids to cluster in a separate region of the membrane.

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