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Marzena Cydzik, Magdalena Rudowska, Piotr Stefanowicz and Zbigniew Szewczuk Derivatization of peptides as quaternary ammonium salts for sensitive detection by ESI-MS Journal of Peptide Science 17

Version of Record online: 24 FEB 2011 | DOI: 10.1002/psc.1342

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A series of model peptides in the form of N-terminal quaternary ammonium salts were efficiently prepared by the solid phase synthesis. Tandem mass spectrometric analysis of the peptide quaternary ammonium derivatives was shown to provide sequence confirmation and enhanced detection. This strategy offers also a significant increase in ionization efficiency, allowing the detection of femtomolar amounts of peptides, which could be useful in analysis of the one-bead-one-compound combinatorial peptide libraries prepared by the split-and-mix method.

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