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Alicia Santos Savio, Osvaldo Reyes Acosta, Haydee Gerónimo Pérez, Yunier Rodríguez Álvarez, Araceli Chico, Hilda Garay Pérez, Miriam Ojeda Ojeda, Celia Aurora Arrieta Aguero, Miguel Estévez and Gerardo Guillen Nieto Enhancement of the inhibitory effect of an IL-15 antagonist peptide by alanine scanning Journal of Peptide Science 18

Article first published online: 2 NOV 2011 | DOI: 10.1002/psc.1411

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IL-15 is a potential target in rheumatoid arthritis. We had identified a peptide (P8) which inhibits binding of IL-15 to IL-15Rα and affects IL-15 biological activity. Here, we studied P8 peptide analogs based on Ala scanning and other punctual mutations. As a result, we found a more active peptide inhibiting both IL-15 biological activity and TNFα secretion by synovial cells

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