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Marina Gobbo, Elisabetta Merli, Barbara Biondi, Simona Oancea, Antonio Toffoletti, Fernando Formaggio and Claudio Toniolo Synthesis and preliminary conformational analysis of TOAC spin-labeled analogues of the medium-length peptaibiotic tylopeptin B Journal of Peptide Science 18

Article first published online: 2 NOV 2011 | DOI: 10.1002/psc.1413

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A set of analogues of the 14-residue peptaibol tylopeptin B, containing the stable free-radical TOAC at one or two selected positions, was synthesized by the solid-phase methodology. A solution conformational analysis performed by FTIR absorption and CD suggests that all of the TOAC analogues retain the conformational preference of the parent peptide, resulting mostly to be helical in solution. Also, they do exhibit membrane-modifying properties comparable with those of tylopeptin B.

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