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Andra Noormägi, Kateryna Primar, Vello Tõugu and Peep Palumaa Interference of low-molecular substances with the thioflavin-T fluorescence assay of amyloid fibrils Journal of Peptide Science 18

Version of Record online: 14 NOV 2011 | DOI: 10.1002/psc.1416

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Basic Blue 41, Basic Blue 12, Azure C and Tannic acid decrease fluorescence intensity of ThT bound to insulin fibrils.

In insulin fibrillization assay monitored by ThT fluorescence, these compounds show apparent inhibition of fibrillization.

Unlike to true inhibitors, these compounds did not decreased the fibrillization rate or increased the lag-period of insulin fibrillization.

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