Koichiro Kitamura, Masayuki Komatsu, Madhu Biyani, Masae Futakami, Tomoyo Kawakubo, Kenji Yamamoto and Koichi Nishigaki Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method Journal of Peptide Science 18
A general method is reported to identify functional peptides and improve their activities, leading to generation of peptides of a pM ordered-dissociation constant.
The key of this technology is in utilizing the information obtained in the previous selection. Namely, the next library for the selection is generated by the combination of the selection products from the preceding library with the construct of peptide-spacer-peptide, which is termed as a paired peptide (p&p) method.
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