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Ellen V. Hackl, Vladimir P. Berest and Sergey V. Gatash Interaction of polypeptide antibiotic gramicidin S with platelets Journal of Peptide Science 18

Article first published online: 19 OCT 2012 | DOI: 10.1002/psc.2461

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The effect of gramicidin S (GS) on platelets and platelet aggregates has been studied. GS interaction with platelets is concentration dependent and leads either to platelet swelling or to platelet shape change/activation. GS induces disaggregation of platelet aggregates. Factors affecting the membrane lipids (temperature, lipid peroxidation and ionising irradiation) change the GS interaction with platelets.

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