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M. M. Rigano, A. Romanelli, A. Fulgione, N. Nocerino, N. D'Agostino, C. Avitabile, L. Frusciante, A. Barone, F. Capuano and R. Capparelli A novel synthetic peptide from a tomato defensin exhibits antibacterial activities against Helicobacter pylori Journal of Peptide Science 18

Version of Record online: 4 NOV 2012 | DOI: 10.1002/psc.2462

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In this work, we used a bioinformatic approach to identify putative defensins, a class of protein exerting broad spectrum antimicrobial activity, in the tomato genome. We selected a representative member of the tomato defensin family; we chemically synthesized its γ-motif and tested its antimicrobial activity. Here, we demonstrate that the synthetic peptide exhibits antibacterial activity against Gram-positive and Gram-negative bacteria, including Helicobacter pylori. Moreover, the synthetic peptide shows minimal hemolytic activity, significant anti-inflammatory properties, and absence of cytotoxic effects.

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