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Hajime Hibino, Yasuyoshi Miki and Yuji Nishiuchi Synthesis and application of Nα-Fmoc-Nπ-4-methoxybenzyloxymethylhistidine in solid phase peptide synthesis Journal of Peptide Science 18

Article first published online: 30 OCT 2012 | DOI: 10.1002/psc.2464

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The 4-methoxybenzyloxymethyl (MBom) group was regioselectively introduced at the π-nitrogen of the imidazole ring of histidine. Fmoc-His(π-MBom)-OH proved to effectively prevent racemization during its incorporation mediated by uronium or phosphonium reagents even in the case of the MW-assisted solid phase peptide synthesis performed at high temperature.

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