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Cristina Peggion, Barbara Biondi, Marta De Zotti, Simona Oancea, Fernando Formaggio and Claudio Toniolo Spectroscopically labeled peptaibiotic analogs: the 4-nitrophenylalanine infrared absorption probe inserted at different positions into trichogin GA IV Journal of Peptide Science 19

Version of Record online: 27 DEC 2012 | DOI: 10.1002/psc.2475

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In this work, we synthesized and extensively characterized three analogs of the lipopeptaibiotic trichogin GA IV, mono-labeled with the IR absorption probe Phe(NO2) at different positions in the amino acid sequence. These analogs preserve the helical conformation, membrane-modifying properties, and in vitro antibacterial activities of the native compound. However, from our IR absorption and attenuated total reflectance IR experiments, the nitrobenzyl probe seems not to be a particularly environment-sensitive reporter group.

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