Cristina Peggion, Barbara Biondi, Marta De Zotti, Simona Oancea, Fernando Formaggio and Claudio Toniolo Spectroscopically labeled peptaibiotic analogs: the 4-nitrophenylalanine infrared absorption probe inserted at different positions into trichogin GA IV Journal of Peptide Science 19
In this work, we synthesized and extensively characterized three analogs of the lipopeptaibiotic trichogin GA IV, mono-labeled with the IR absorption probe Phe(NO2) at different positions in the amino acid sequence. These analogs preserve the helical conformation, membrane-modifying properties, and in vitro antibacterial activities of the native compound. However, from our IR absorption and attenuated total reflectance IR experiments, the nitrobenzyl probe seems not to be a particularly environment-sensitive reporter group.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf