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Hajnalka Szabados, Szilvia Bősze, Pálma Silló, Sarolta Kárpáti, Ferenc Hudecz and Katalin Uray The mapping of linear B-cell epitope regions in the extracellular parts of the desmoglein 1 and 3 proteins: recognition of immobilized peptides by pemphigus patients' serum autoantibodies Journal of Peptide Science 19

Article first published online: 8 JAN 2013 | DOI: 10.1002/psc.2476

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Pemphigus specific epitope regions were identified in desmoglein 1 and 3 proteins with pin-bound synthetic 15-mer peptides and modified ELISAs by testing serum antibodies from patients and healthy donors. The serum antibodies of the healthy individuals did not show any specific recognition. Not only conformational but also linear epitope regions are spread in the entire extracellular region of the desmoglein 1 protein.

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