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Franziska Thomas Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligation in parallel formats Journal of Peptide Science 19

Article first published online: 7 FEB 2013 | DOI: 10.1002/psc.2494

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An Fmoc-based peptide thioester synthesis with self-purifying effect is described. A cyclization–thiolysis reaction sequence on the sulfonamide ‘safety-catch’ linker allows the selective detachment of the truncation products and the full-length peptide thioester. The method paves the way for the parallel synthesis of peptide thioesters and consequently expands the applicability of the native chemical ligation to the synthesis of parallel formats such as protein arrays.

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