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Anna V. Kutina, Anna S. Marina, Ivan I. Eliseev, Mikhail I. Titov and Yuri V. Natochin Synthesis of new vasotocin analogues: effects on renal water and ion excretion in rats Journal of Peptide Science 19

Article first published online: 27 MAR 2013 | DOI: 10.1002/psc.2495

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New analogues of antidiuretic hormones (vasotocin and vasopressin) were synthesised by solid-phase technology. Peptides modified at positions 4 and 8 exerted discriminative effects on water reabsorption and excretion of sodium and potassium. Synthesised vasotocin analogues could be good candidates for pharmaceuticals selectively regulating not only water but also sodium and potassium renal transport, which is of clinical importance.

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