E-mail

E-mail a Wiley Online Library Link

Brandon L. Kier and Niels H. Andersen Captides: rigid junctions between beta sheets and small molecules Journal of Peptide Science 20

Article first published online: 6 JUN 2014 | DOI: 10.1002/psc.2657

Thumbnail image of graphical abstract

We investigated the effect of over 60 different monocarboxylic and polycarboxylic acids as integral components of the beta cap structural motif. Upon ligation, the small molecule is rigidly held in a precise, partly buried environment; fold-dependent rigidity sets this strategy apart from currently flexible bioconjugation methods. Applications to catalyst enhancement, drug design, higher-order assembly, and FRET calibration rulers are discussed.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH