Brandon L. Kier and Niels H. Andersen Captides: rigid junctions between beta sheets and small molecules Journal of Peptide Science 20
We investigated the effect of over 60 different monocarboxylic and polycarboxylic acids as integral components of the beta cap structural motif. Upon ligation, the small molecule is rigidly held in a precise, partly buried environment; fold-dependent rigidity sets this strategy apart from currently flexible bioconjugation methods. Applications to catalyst enhancement, drug design, higher-order assembly, and FRET calibration rulers are discussed.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf