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Brandon L. Kier and Niels H. Andersen Captides: rigid junctions between beta sheets and small molecules Journal of Peptide Science 20

Article first published online: 6 JUN 2014 | DOI: 10.1002/psc.2657

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We investigated the effect of over 60 different monocarboxylic and polycarboxylic acids as integral components of the beta cap structural motif. Upon ligation, the small molecule is rigidly held in a precise, partly buried environment; fold-dependent rigidity sets this strategy apart from currently flexible bioconjugation methods. Applications to catalyst enhancement, drug design, higher-order assembly, and FRET calibration rulers are discussed.

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