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Jorge Rafael León-Carmona and Annia Galano Free radical scavenging activity of caffeine's metabolites International Journal of Quantum Chemistry 112

Article first published online: 3 APR 2012 | DOI: 10.1002/qua.24084

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Considering the relatively high amount of caffeine in coffee, significant quantities of its metabolites are anticipated in blood and might be involved in the physiological effects related to coffee consumption, including antioxidant protection. The free radical scavenging activity of paraxanthine (PAR), theobromine (THB), theophylline (THP) and 1-methylxanthine (MXT) was studied and it was found to be higher in non-polar environment than in aqueous solution, and similar to that of their precursor caffeine.

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