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Chunling Wang, Xiaoke Yang, Endong Wang and Baiqing Li Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes International Journal of Quantum Chemistry 113

Version of Record online: 25 SEP 2012 | DOI: 10.1002/qua.24333

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A new reaction mechanism, which does not involve direct transfer of a methyl group from a radical S-adenosylmethionine enzyme to adenosine, is proposed for a pair of methyltransferase reactions. The activation barriers, calculated using density functional theory, indicate that the proposed reaction mechanism is plausible and the formation of a disulfide bond is likely the rate-limiting step.

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