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G. H. Zeng, D. Q. Fang, W. J. Wu, R. Zhang, W. G. Xie, J. H. Wu and Y. Shen Binding conformations, QSAR, and molecular design of Alkene-3-quinolinecarbonitriles as Src inhibitors International Journal of Quantum Chemistry 113

Version of Record online: 29 OCT 2012 | DOI: 10.1002/qua.24344

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c-Src kinase, a nonreceptor protein tyrosine kinase, is found to be upregulated in many forms of tumors. A novel series of alkene-3-quinolinecarbonitriles acting as Src inhibitors is studied theoretically and eight compounds with high predicted inhibitory activities are identified.

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