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Rita Kakkar and Mamta Bhandari Theoretical investigation of the alloxan–dialuric acid redox cycle International Journal of Quantum Chemistry 113

Article first published online: 23 MAR 2013 | DOI: 10.1002/qua.24441

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Alloxan has long been used to induce diabetes in experimental animals in studies on diabetes mellitus, a metabolic disorder that affects several million people worldwide. The alloxan–dialuric acid redox cycle is believed to be responsible for the diabetogenecity of alloxan. Herein, the mechanism involved in this redox cycling is investigated, and it is found that alloxan is reduced by glutathione to the dialuric acid anion, which undergoes aerial oxidation to generate cytotoxic superoxide radicals, causing β-cell toxicity.

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