Jinfeng Zhao, Chuanzhi Sun, Nan Sun, Lin Meng and Dezhan Chen Theoretical study on the mechanism of the reaction for alkene hydroaminations catalyzed by chiral aldehyde International Journal of Quantum Chemistry 113
Alkene hydroamination catalyzed by chiral aldehyde, based on temporary intramolecularity, is a new concept in chemistry. To clarify the reaction mechanism, alkene hydroamination of N-benzylhydroxylamine and secondary allylic amine is modeled using DFT. The chiral catalyst allows the key formation of a mixed aminal species, resulting in a facile intramolecular hydroamination event. Simple aldehyde precatalyst enables the synthesis of vicinal diamines through temporary intramolecularity.
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