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Pradeep Kumar Shukla and P.C. Mishra Base pairing patterns of DNA base lesion spiroiminodihydantoin: A DFT study International Journal of Quantum Chemistry 113

Article first published online: 10 JUL 2013 | DOI: 10.1002/qua.24512

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DNA in living organisms is attacked by reactive oxygen and nitrogen oxide species, free radicals, alkylating agents, and so forth, produced endogenously and exogenously, leading to diseases like cancer. Spiroiminodihydantoin (Sp) is formed due to the oxidation of guanine and 8-oxoguanine. This work investigates the base pairing patterns of Sp with each of the normal DNA bases and finds that the strong Sp–guanine abnormal base pairing may be the main cause of the observed mutagenicity of Sp.

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