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Kwang Ho Lee, Su Jung Shin, Yongdoo Park and Sang-Hoon Lee Synthesis of Cell-Laden Alginate Hollow Fibers Using Microfluidic Chips and Microvascularized Tissue-Engineering Applications Small 5

Article first published online: 19 MAR 2009 | DOI: 10.1002/smll.200801667

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Alginate-only, cell-laden, and protein-immobilized hollow fibers are produced (see image). Cells remain alive within the hollow fibers due to the nontoxic fabrication process. Vascular tissue can be emulated by embedding endothelial cells into the alginate hollow fibers and then embedding these cell-laden fibers into smooth-muscle-cell-laden AGF hydrogels.

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