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Zhiwen Tang, Hong Wu, John R. Cort, Garry W. Buchko, Youyu Zhang, Yuyan Shao, Ilhan A. Aksay, Jun Liu and Yuehe Lin Constraint of DNA on Functionalized Graphene Improves its Biostability and Specificity Small 6

Version of Record online: 11 MAY 2010 | DOI: 10.1002/smll.201000024

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Single-stranded DNA constrained on a graphene surface is effectively protected from enzymatic cleavage by DNase I. Various spectroscopy studies suggest that the single-stranded DNA is promptly adsorbed onto graphene forming strong molecular interactions. Constraint of the DNA probe on the graphene surface improves the specificity of its response to complementary DNA.

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