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Santosh Aryal, Che-Ming Jack Hu and Liangfang Zhang Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery Small 6

Article first published online: 17 JUN 2010 | DOI: 10.1002/smll.201000631

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Two drugs are loaded onto the same drug-delivery nanocarrier in a controllable manner by covalently preconjugating the therapeutic agents through hydrolyzable linkers to form drug conjugates. The cleavable linkers allow the therapeutic activity of the individual drugs to be resumed after the conjugates are delivered into the target cells.

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