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Per Ola Andersson, Christian Lejon, Barbro Ekstrand-Hammarström, Christine Akfur, Linnéa Ahlinder, Anders Bucht and Lars Österlund Polymorph- and Size-Dependent Uptake and Toxicity of TiO2 Nanoparticles in Living Lung Epithelial Cells Small 7

Article first published online: 24 JAN 2011 | DOI: 10.1002/smll.201001832

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The cellular uptake and distribution of anatase and rutile TiO2 nanoparticles and the intracellular oxidative stress they induce in lung epithelial cells are shown to correlate with their intrinsic physicochemical properties. Uptake is found to be kinetically activated and strongly dependent on the hard agglomeration size. In-vitro Raman microspectroscopy facilitates size- and polymorph-specific discrimination of particles inside cells.

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