E-mail

E-mail a Wiley Online Library Link

Bryan Ronain Smith, Zhen Cheng, Abhijit De, Jarrett Rosenberg and Sanjiv Sam Gambhir Quantum dots: Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy (Small 20/2010) Small 6

Version of Record online: 13 OCT 2010 | DOI: 10.1002/smll.201090071

Thumbnail image of graphical abstract

The frontispiece image shows tumor (green) at the microscopic level in living mice. Within the tumor, blood vessels in red are easily visible. When targeted, nanoparticles (quantum dots, shown in white) bind as aggregates in a similar way to three different types of tumor (one example is shown at bottom left). However, when controls are used, very little binding takes place as shown in the other images. Data indicate that vascular targeting may be a robust and reliable method to promote nanoparticle accumulation in a tumor, as opposed to extravasation, which is shown to be highly heterogeneous. For more information, please read the Full Paper “Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy” by S. S. Gambhir and co-workers, beginning on page 2222.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH