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Jin Wang, James D. Byrne, Mary E. Napier and Joseph M. DeSimone More Effective Nanomedicines through Particle Design Small 7

Version of Record online: 22 JUN 2011 | DOI: 10.1002/smll.201100442

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Nanomedicine is an emerging field that applies concepts in nanotechnology to the development of novel diagnostics and therapeutics. Physical and chemical properties of particles, including size, shape, modulus, surface charge, and surface chemistry, play important roles in the efficacy of nanomedicines. This review focuses on the effect of particle physical and chemical properties on their interactions with cells in vitro and their pharmacokinetics and biodistribution in vivo.

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