Poornima Kolhar, Nishit Doshi and Samir Mitragotri Polymer Nanoneedle-Mediated Intracellular Drug Delivery Small 7
Intracellular delivery using needles: Needle-shaped particles made from a biodegradable polymer, PLGA, are shown to deliver siRNA into cells with minimal toxicity. The particles lead to higher intracellular delivery compared to spheres by direct penetration into the cell membrane resulting in higher gene knockdown. The particles are engineered to switch to spherical shape on demand mitigating the toxicity due to continuous permeabilization.
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